PGS/PGT-A/CCS (Comprehensive Chromosomal Screening). Testing the embryo as responsible for sterility

Chromosomal testing of embryos throws light on their condition and the source of previous implantation failures or recurrent miscarriages

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It should be kept in mind that in order to successfully bring a pregnancy to full term without Assisted Reproduction or without having received treatment for a reproductive disorder, there are three patients who must remain healthy: the man, the woman and the embryo. It is not a matter of twos but of threes, and we are starting to realize that the third patient is responsible for many infertility problems traditionally labeled as “of unknown causes” or the result of “bad luck”.

We hardly know the embryo. Our assessments of it were too simplistic: they were based on its morphology, that is, the shape it takes on the days when it is cultured, the number of cells it has, the time it takes to split,… In other words, its external appearance.

The search for clues that would make embryo selection more reliable and expand our knowledge about its health has been continuous over the last years.

We knew that chromosomal alterations are responsible for most early miscarriages and failed insemination and IVF (In vitro fertilisation) treatments, but we lacked reliable techniques that would not damage the embryo.

Luckily for both patients and doctors, this situation has changed dramatically: today, comprehensive tests of all chromosomes present in an embryo are a reality.

How is PGS/PGT-A/CCS performed?

A sample of the embryo’s external layer (its future placenta) is taken; cells are then tested, and the number of its chromosomes, which carry genetic information, is determined.

What advantages does PGS/PGT-A/CCS have for me as a patient?

It allows us to discard those embryos traditionally regarded as “good quality” for their appearance but which, because they were carriers of chromosomal alterations, ended either not implanting or causing pregnancy losses during the first weeks.

What advantages does CCS have for me as a patient?

When should PGS/PGT-A/CCS be performed?

This test is advised in cases of previous IVF or insemination failure, recurrent miscarriage or miscarriage for unknown causes, and chromosomal abnormalities in patients or their families.

THE ADVANTAGES OF COMPREHENSIVE CHROMOSOME SCREENING

Avoids unnecessary thawing
and transfer of abnormal embryos which, based on shape,

may appear to be apt but which, in terms of chromosomes, are not

Suitable embryo selection which takes into account both

morphological and chromosomal criteria

Reduces the risk

of pregnancy loss

Biopsy on day 5,
avoid damage to the internal cell mass

of the embryo

Avoids multiple transfers which can

lead to multiple pregnancies

Greater precision
in el

diagnosis