A breakthrough in the diagnosis of low ovarian reserve linked to Interleukin-10 levels

A new research from Instituto Bernabeu associates the state of the patient’s cytokines with the diagnosis of low ovarian reserve and response. The conclusions of the work were presented in the last edition of the European Society of Human Reproduction and Embryology (ESHRE) congress, which took place between the 6th and 9th of July.

Although some studies show evidence of the possible effect of the immune system on ovarian function and the embryo implantation process, its role in the success of assisted reproduction treatments remains unknown. Our aim was to investigate the effect of cytokines on ovarian reserve and response.

Our study shows that interleukin-10 level is decreased in patients with low ovarian reserve and response compared to patients with normal reserve and response.

In addition, if interleukin-10 levels are below 0.5 pg/ml, the treatment customization may not improve results.

In conclusion, interleukin-10 could be useful as a biomarker to predict ovarian response in the light of a possible assisted reproductive treatment.

Poor ovarian reserve and response are associated with interleukin 10 levels in women undergoing in-vitro fertilization

A. Fabregat, M. Hortal, B. Lledó, J.A. Ortiz, A. Bernabeu, J. Ll. Aparicio, R. Bernabeu