Instituto Bernabeu researches new ways of optimising oocyte retrieval during ovarian stimulation in donation cycles

Instituto Bernabeu has submitted research work about optimisation of ovarian stimulation in oocyte donation cycles to the European Society of Human Reproduction and Embryology (ESHRE). The research involves using oral progesterone instead of the GnRH antagonist, the alternative pharmaceutical drug that has traditionally been used to control when ovulation takes place. The main advantage of this strategy is how easy it is for patients because it entails fewer injections.

During their research, experts from Instituto Bernabeu observed that using progesterone was sufficient in order to avoid inhibiting premature ovulation. However, the number of oocytes that were retrieved in these cases was lower than in conventional cycles. Nonetheless, and with reference to this last point, the results cannot be given conclusive status because of the small number of cases that were included in the study. Additional and larger studies confirming the efficiency of this alternative means of ovarian stimulation are necessary in order to obtain conclusive results.

Exploring outcomes with the use exogenous progesterone to replace the use of an antagonist in egg-donation cycles

J. Guerrero; J. Castillo; R. Delgado; B. Moliner; L. Luque; J. Ten; A. Fuentes; A. Herencia; D. Bodri; P. Cirillo; A. Bernabéu; J. Ll. Aparicio; R. Bernabéu.